Endothelial nitric oxide synthase gene polymorphism is associated with Legg-Calvé-Perthes disease

Osteochondritis dissecans following Legg-Calvé-Perthes' disease.

Editorial LEGG - CALVÉ - PERTHES DISEASE : 100 YEARS

Legg-Calvé-Perthes disease (LCPD) started to be studied 100 years ago (1910), thanks to the advent of the possibility of conducting clinical studies by means of radiographic images (1895). However, many questions remain open, both in relation to the etiology of this orthopedic condition and in relation to which therapeutic measures are valid. Thus, great controversy has been generated. In 1910,...

Legg-Calvé-Perthes disease: current concepts.

Perthes is a serious but self-limited disorder. If it is a self limiting disease, then why one should think of treating it. The aim of treatment is to prevent femoral head deformity and subsequent osteoarthrosis. There is still no clear guideline for the management of Perthes disease. This is because of the controversies in all most all the aspects of the disease; etiology, classification, natu...

Association of endothelial nitric oxide synthase gene G894T polymorphism with type two diabetes and diabetic nephropathy

Background: Nitric oxide (NO) produced by endothelial NO synthase (eNOS) mediates a large range of processes, and abnormality in the production of NO has been implicated in diabetic complications including diabetic nephropathy (DN). G894T polymorphism in the eNOS gene has been shown to decreased activity the NO levels of plasma. The association between eNOS Glu298Asp gene polymorphism and DN ri...

Legg-Calvé-Perthes disease in a child with osteopetrosis

Osteopetrosis is a rare inherited disorder of bone causing increased bone density. Legg-Calvé-Perthes disease (LCPD), by contrast, is a more common idiopathic condition leading to variable avascular necrosis of the immature femoral head. We present a case of a 5-year-old boy presenting with these co-morbidities. We have found only one previous reference suggesting these two conditions can coexi...